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Metformin increases 18F-FDG flux and inhibits fatty acid oxidation at clinical doses in breast cancer: Results of a phase 0 clinical trial

Simon Lord,Dan Liu,Wei-Chen Cheng,Syed Haider,Edoardo Gaude,Eugene Teoh,Neel Patel,Tom Metcalf,Daniel R. McGowan,Ioannis Roxanis,Zhang Qifeng,Pankaj Roy,Fergus V. Gleeson,Alastair M. Thompson,Michael Pollak,Michael J. O. Wakelam,Francesca M. Buffa,Christian Frezza,John D. Fenwick,Adrian L. Harris

European Journal of Surgical Oncology (EJSO)（2016）

Cited 1|Views23
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Abstract
Background: Over 100 clinical trials are underway worldwide to investigate the anticancer effects of the diabetes drug, metformin. However, it is still not determined as to whether metformin has significant direct effects on cancer cells or solely indirect effects via modulation of host metabolism.
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fatty acid oxidation,breast cancer,f-fdg
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