Polysaccharide from Polygonatum Inhibits the Proliferation of Prostate Cancer-Associated Fibroblasts Cells

Prostate cancer affects a gland in the male reproductive system. The cancer cells may spread from the prostate to other parts of the body, particularly bones and lymph nodes. Initially, patients may not have any symptoms. In the later stages, prostate cancer can result in difficulty urinating, blood in the urine, or pain in the pelvis or back when urinating. Prostate cancer is the most common noncutaneous cancer diagnosed among American men and the second leading cause of cancer death. Known risk factors for prostate cancer are increased age, African American race, and positive family history of the disease. As a result, developing adequate therapy for prostate cancer is an important medical goal. One of the most frequently used modalities for treating locally advanced prostate cancer, in addition to radical prostatectomy (RP) and radiation therapy (RT), is androgen-deprivation therapy (ADT).2 The endocrine therapy used to treat prostate cancer aims to eliminate the androgenic activity in the prostatic tissue. Polygonatum, belonging to Liliaceae polygonatum, is a dried rhizome of perennial herb that has been used in traditional Chinese medicine. Polysaccharides from polygonatum exhibit strong anti-cancer activities. In the tumor microenvironment, fibroblasts are one of the most abundant cell types. CAFs promote tumor progression through producing an