Development and Manufacturing GMP Scale-Up of a Continuous Ir-Catalyzed Homogeneous Reductive Amination Reaction

Scott A. May,Martin D. Johnson,Jonas Y. Buser,Alison N. Campbell,Scott A. Frank,Brian D. Haeberle,Philip C. Hoffman,Gordon R. Lambertus,Adam D. McFarland,Eric D. Moher,Timothy D. White,D. Declan Hurley, Aoife P. Corrigan,Olivia Gowran,Niall G. Kerrigan,Marie G. Kissane, Regina R. Lynch,Paul Sheehan,Richard D. Spencer,Shon R. Pulley,James R. Stout

Organic Process Research & Development（2016）

引用 62|浏览45

关键词

Evacetrapib,continuous manufacturing,flow chemistry,hydrogenation,hydrogen,reductive amination,GMP,lot genealogy,deviation boundaries,start up and shutdown transitions,homogeneous catalysis,iridium,[Ir(COD)Cl]2,process analytical technologies,steady state,state of control,LY2484595,online HPLC

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