GW27-e1103 An Updated Systematic Review and Meta-analysis of the Short- and Long-term Outcomes of Percutaneous Coronary Intervention for Patients with Severe Left Ventricular Systolic Dysfunction

Background: Coronary artery disease (CAD) is the most common cause of left ventricular dysfunction (LVD).Confl icting evidence exists with regards to available treatments and patient prognosis.Revascularization may improve ventricular function while coronary artery bypass surgery (CABG) has signifi cantly improved survival.The effectiveness of percutaneous coronary intervention (PCI) has also not been thoroughly investigated to date.Objectives: To ascertain the in-hospital and long-term (≥1 year) outcomes of CAD patients with LV systolic dysfunction (ejection fraction ≤40%) after PCI according to a meta-analysis.Methods: A systematic literature search and a series of random-effect meta-analyses were conducted to evaluate the short-and long-term outcomes of PCI of the selected studies.Single-center studies and those that did not report evidence on long-term mortality were excluded in the analysis.All statistical tests were performed with 95% confi dence intervals.A p-value of less than 0.05 was considered statistically signifi cant.Results: A total of 25 studies involving 5,471 patients (78% males, average age 65.1 years) were identifi ed.The average follow-up duration was approximately 27 months.The majority of patients had multi-vessel disease (68%), hypertension (66%), hypercholesterolemia (59%), and prior myocardial infarction (MI) (58%).The meta-analysis showed that the in-hospital occurrence of major adverse cardiac events (MACE), deaths, MI, and repeat revascularization (RR) after PCI were controlled at 4%, 2%, 2%, and 1%, respectively.The pooled estimates for long-term outcome were 40% MACE, 20% deaths, 4% MI, and 21% RR.There was no signifi cant difference in mortality risk when PCI was compared with CABG (p=0.71). Conclusion:PCI carries acceptable short-and long-term outcomes for CAD patients with LV systolic dysfunction.