Solubility measurement, model evaluation and thermodynamic analysis of rivaroxaban polymorphs in organic solvents

Jinghuan Zhai,Zhenzhen Chen,Xijian Liu, Lijuan Zhang,Jie Lu

The Journal of Chemical Thermodynamics（2017）

引用 26|浏览9

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摘要

•The solubility of form II of rivaroxaban in organic solvents was firstly reported.•Wilson, NRTL and UNIQUAC were evaluated to model the solubility.•The apparent standard enthalpy change of the dissolution of both forms was analyzed.

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关键词

Solubility,Polymorph,Rivaroxaban,Measurement,Thermodynamic modelling

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