Topical thioredoxin inhibits IL-6 and IL-1beta production from keratinocytes and is effective for psoriasis-like dermatitis in mice

Thioredoxin (TRX) is a 12-kDa small protein, which has anti-oxidant properties and plays crucial roles in the redox regulation of cellular signaling and activation. Systemic administration or transgenic overexpression of TRX is known to ameliorate several animal inflammation models.