Thromboprophylaxis With Aspirin For Newly Diagnosed Multiple Myeloma Treated With Thalidomide Plus Dexamethasone: A Preliminary Report.

Background The pathogenesis of thalidomide induced DVT is poorly understood. It has been suggested that effect may involve a direct action of thalidomide on endothelial cells previously damaged by chemotherapy agents. The purpose of the present study was to examine the efficacy of daily low-dose (81 mg orally) in decreasing the incidence of venous thromboembolic events (VTE's) in patients with multiple myeloma receiving thalidomide plus dexamethasone as primary therapy and the comparison with a control group of MM patients without aspirin.