Targeting mTOR/PI3K in Primary CNS Lymphoma (PCNSL)

Agnieszka Korfel,Elisabeth Schorb,Uwe Schlegel,Saša Dimitrijević Dimitrijević, Saana D'Allonzo, Martin Dreyling,Ullrich Herrlinger,Philipp Kiewe

Clinical Lymphoma, Myeloma & Leukemia（2016）

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摘要

The prognosis of PCNSL remains worse than that of other diffuse-large B-cell lymphomas. Thus, there is a big need for further therapeutic improvement. Dysregulation of various cellular pathways, such as NFkB, toll-like receptor or B-cell receptor signaling have been reported in PCNSL and constitute a potential therapeutic target.

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关键词

primary cns lymphoma,pcnsl,mtor/pi3k

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