P119 Effects of Aerosolized Interferon Gamma on the Lung Microbiome and Host Immune Tone.

Melissa Lesko, Jing Wang,Yonghua Li,Gerald C. Smaldone,Rany Condos,Leopoldo N. Segal

QJM: An International Journal of Medicine（2016）

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摘要

Background: Therapies targeting the inflammatory process revealed inconsistent results in Idiopathic Pulmonary Fibrosis (IPF). Aerosolized Interferon Gamma (IFN-y) has been proposed as a novel therapy. Additionally, changes in the host airway microbiome have been associated with inflammatory tone and, in IPF, may be associated with disease progression. We evaluate whether …

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