Synthesis of 3-(4-aminophenyl) cyclopropane-1, 1,2,2-tetracarbonitrile

3-(4-aminophenyl) cyclopropane-1, 1, 2, 2-tetracarbonitrile (1) is an important intermediate which used to synthesize NVP-BEZ-235 derivative. In this work, a rapid synthetic method for compound 1 was established. The 3-(4-aminophenyl) cyclopropane-1, 1, 2, 2-tetracarbonitrile was synthesized from the commercially available 4-nitrobenzaldehyde through three steps. The structure was confirmed by MS and (HNMR)-H-1. Furthermore, the synthetic method was optimized. The total yield of the three steps was 65.25% (caculated from malononitrile).