Characterization And Functional Modulation Of Hbv-Specific Cd4+T Cell Responses
JOURNAL OF HEPATOLOGY(2016)
摘要
CD4+ T cells are central regulators of both humoral and cellular immunity. In the context of chronic HBV-infection, HBV-specific CD4 T cells are reduced in numbers and functionally impaired. Since current therapies fail to offer a cure from chronic HBV-infection, novel therapeutic concepts involving immunotherapy are desperately needed. The functional modification of HBV-specific CD4+ T cells may represent a promising approach to improve immunotherapeutic strategies.
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关键词
hbv-specific
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