Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS

A HPLC-MS method had been developed and applied to investigate the influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate. The changes in the pharmacokinetic behavior indicated that the pretreatment of piperazine ferulate might exert the protective effect on methotrexate-induced renal injury.