Study On The Relationship Between Red Cell Distribution Width And The Increase Of Uric Acid In Chinese Hypertensive Patients

Objective: We hypothesized that red cell distribution width (RDW) would be associated with increases in serum uric acid (UA) in hypertension patients. Design and method: All subjects were participants of the China Stroke Primary Prevention Trial (CSPPT, clinicaltrials.gov identifier: NCT00794885). This study was a randomized, doubleblind clinical trial conducted from May 19, 2008, to August 24, 2013. 15486 participants provided written informed consent. Eligible participants were men and women aged 45 to 75 years old who had hypertension, defined as seated resting systolic blood pressure of 140 mmHg or higher or diastolic blood pressure of 90 mmHg or higher at both the screening and recruitment visits or were taking an antihypertensive medication. Participants were scheduled for follow-up every 3 months. At each follow-up visit, vital signs, study drug adherence, concomitant medication use, adverse events, and possible endpoint events were documented by trained research staff and physicians. For testing the primary hypothesis, the efficacy analyses for the primary outcome were conducted according to the ITT principle. All analyses were performed using EmpowerStats (http://www.empowerstats.com) and the statistical package R. Data are presented as mean ± standard deviation (SD) or proportions. Results: There was a strong relationship between RDW level and UA increase. In the following cases, we can see the same relationship: UA increase value and the increase rate rised with RDW increasing in patients less than and greater than 60 years old (P < 0.05). Whether hypertensive patients taking enalapril or enalapril-folic acid tablets, the level of UA and RDW were into a significant positive correlation (P < 0.05). In patients with normal or elevated mean-SBP, UA also rised with the rising of RDW (P < 0.05). Conclusions: In hypertension patients, the UA increase with the rising of RDW. We also evaluated the relationship could not be affected by other variables including gender, age, anti-hypertensive drugs mean-SBP and mean-DBP.