Association between gait, cognition and grey matter volumes in MCI and Healthy controls
Gait & Posture(2016)
摘要
Human multi-segmental motion is a complex task requiring motor coordination. Uncoordinated motor control may contribute to the decline in mobility; however, it is unknown whether the age-related decline in intersegmental coordination relates to the decline in gait performance. The aim of this study was to clarify the association between intersegmental coordination and gait speed in elderly females. Gait measurements were performed in 91 community-dwelling elderly females over 60 years old. Foot, shank, and thigh sagittal motions were assessed. Intersegmental coordination was analyzed using the mean value of the continuous relative phase (mCRP) during four phases of the gait cycle to investigate phase differences in foot–shank and shank–thigh motions during a normal gait. The results showed that foot–shank mCRP at late stance had negative correlations with gait speed (r = −0.53) and cadence (r = −0.54) and a positive correlation with age (r = 0.25). In contrast, shank–thigh mCRP at late stance had positive correlations with gait speed (r = 0.37) and cadence (r = 0.56). Moreover, partial correlation, controlling age, height, and weight, revealed that foot–shank mCRP at late stance had negative correlations with gait speed (r = −0.52) and cadence (r = −0.54). Shank–thigh mCRP at late stance had a positive correlation with gait speed (r = 0.28) and cadence (r = 0.51). These findings imply that the foot–shank and shank–thigh coordination patterns at late stance relate to gait speed, and uncoordinated lower limb motion is believed to be associated with the age-related decline in cadence.
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关键词
gait,grey matter volumes,cognition,mci
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