Acute Phase Reactants In Generalized Tonic-Clonic Epileptic Patients

Background: There is an increasing evidence to support a role of inflammatory processes in epilepsy. Objective: In this study, we will focus on the possible role of inflammation by measuring Ceruloplasmin and High Sensitive CRP (hs-CRP) levels in Generalized Tonic-Clonic Epileptic Patients. Patients and methods: The study groups consisted of thirty-four Generalized Tonic-Clonic Epileptic Patients who were on monotheraphy of AEDs and thirty-four Generalized Tonic-Clonic Epileptic Patients who were on polytherapy with control group of thirty healthy individuals. Informed consent for participation in this study was obtained from all participants. The serum of blood samples was then separated from the cells by centrifugation, and were stored at −80 °C until analysis. Results: hs-CRP levels were significantly higher in the group using antiepileptic drug polytherapy to control group (p = 0.00). hs-CRP values in the group using antiepileptic drug monotherapy were was significantly higher compered to control group (p = 0.02). hs-CRP levels in the group using antiepileptic drug polytherapy group was significantly higher statistically significant compared to the group of using antiepileptic drug monotherapy (p = 0.00). To compare the Ceruloplasmin levels in the patient group and the control group difference was not statistically significant (p = 0.58). Conclusion: Finally, inflammation seems to contribute to epileptogenesis. Based on the available data, we highlight the need for further studies dissecting the exact role of inflammation in epilepsy during development. Our findings demonstrate a relevant relationship between epilepsy and systemic inflammation, with a consistent link between seizures early acute phase markers (hs-CRP).