Dendritic Cells And Cd8+Lymphocytes In Early Mycosis Fungoides.

Dendritic cells (DCs) are immune accessory cells involved in the uptake, processing and presentation of antigens to reactive T cells. In Mycosis fungoides (MF), they are increased when compared to healthy skin, although their role has not yet been elucidated. The activation of the so called TILs (tumor infiltrating lymhocytes) is more efficient when DCs have completed their maturational process. Therefore, blockage of DCs maturation by MF neoplastic cells could represent a mechanism of tumoral escape.