Synthesis and antimicrobial studies of azomethine and N-arylamine derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-methicillin-resistant Staphylococcus aureus agents

Antimicrobial resistance to antibiotics is a global concern. Without urgent and coordinated action, the world is moving towards a post-antibiotic era, in which normal infections or minor injuries may become fatal. In an effort to find new agents to combat this resistance, we report the synthesis and antimicrobial activities of 1,3-diphenyl pyrazole derivatives. Several compounds have shown growth inhibition up to 24 mm in size against Staphylococcus aureus inhibition studies. We tested the active compounds against methicillin-resistant Staphylococcus aureus in minimum inhibitory concentration tests and found activity as low as 16 μg/mL.