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Inducing metabolic suppression in severe hemorrhagic shock: Pilot study results from the Biochronicity Project.

George E Black,Kyle K Sokol,Robert R Shawhan,Matthew J Eckert,Shashikumar Salgar,Shannon T Marko,Zachary S Hoffer, Christopher C Keyes,Mark B Roth,Matthew J Martin

The journal of trauma and acute care surgery（2016）

Cited 7|Views8
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Abstract
Phosphoinositol-3-kinase inhibition produced metabolic suppression in healthy and injured swine without increasing end-organ injury or systemic physiologic markers and demonstrated prolonged efficacy in injured animals. Further study may lead to targeted therapies to prolong tolerance to hemorrhage and extend the "golden hour" for injured patients.
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Key words
Hemorrhage,LY294002,suspended animation,trauma,Yorkshire swine
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