P53 Disruptive Mutation Is A Negative Predictive Factor In Egfr M+ Nsclc Treated With Tki
European Journal of Cancer(2015)
Abstract
Background: p53 mutations are common in lung cancer, and have also been described in EGFR mutated patients. The impact of p53 mutations in EGFR M+ patients is controversial, especially if classified as “disruptive” and “non-disruptive” according to their functional effect on the p53 protein as proposed by Poeta and colleagues. The aim of the study was therefore to systematically analyze EGFR and p53 mutations within a cohort of patients with lung cancer stage IV (UICC 7), to correlate alterations with clinical characteristics and to investigate a potential impact of p53 mutations on treatment outcome.
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Key words
EGFR mutation,p53 disruptive mutation,p53 nondisruptive mutation
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