Desulfitative Palladium‐catalyzed Direct C‐3 Arylation of Indolizines with Arylsulfonyl Chlorides
Chem Inform(2015)
Abstract
An efficient Pd‐catalyzed desulfitative approach to C‐3 arylation of indolizine derivatives has been developed, and the protocol uses readily available arylsulfonyl chlorides as the arylation reagent under nitrogen. This transformation was performed in a mixed solvent of 1‐methyl‐2‐pyrrolidone and dimethoxyethane using simple triphenylphosphine as a ligand, which provides a new method for the C‐3 arylation of indolizines. Copyright © 2015 John Wiley & Sons, Ltd.
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Key words
desulfitative arylation,indolizines,arylsulfonyl chlorides
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