Feasibility And Efficacy Of Concomitant Chemoradiation (Ch-Rt) In The Management Of Newly Diagnosed Elderly Glioblastoma (Gb) Patients: Results From The Gliocat Study.

2045Background: Elderly GB patients have a dismal prognosis. The optimal treatment in this population remains to be established. Methods: We performed a multicenter retrospective and prospective study of newly diagnosed GB patients (pts) treated with standard Ch-RT (Stupp regimen). In the present substudy we analyzed clinical outcome and prognostic factors in elderly ( u003e 65 y) pts and compare these to younger pts from the global cohort. Results: Between 2005 to 2014, 432 pts were enrolled. There were 148 u003e 65y; 117 (79%) 65-75y and 31 (21%) u003e 75y with a mean age of 72y, mean KPS 80%, and 58.8% were males. In pts u003e 65y, gross total resection (GTR) was performed in 34 (24.5%), and biopsy in 29 (20.9%) with postoperative complications in 17 (11.5%). The time to initiate Ch-RT was 4.93 weeks (w); 127 (85.8%) finished Ch-RT and 109 (73.6%) completed adjuvant temozolomide (TMZ). Only 16 (10.8%) could discontinue steroids during the concomitant therapy. There were 28 (18.9%) patients with pseudoprogression. MGMT...