Women With Epilepsy: Fertility Rate, Reproductive Endocrine Complications

Reproductive health gained great social value in connection with aggravated problem of quality and quantitative reproduction in population. Objective: to study fertility rate (FR), reproductive endocrine complications (REC) frequency in women with epilepsy Methods: 155 women at the age of 16 – 45 were included in the prospective observation research of REC due to antiepileptic drugs (AEDs) into 3 groups: 1gr. - AEDs monotherapy, 2 gr. - polytherapy, 3 gr. - without AEDs. FR and REC frequency were studied in groups. Definition of interrelation "AEDs - REC" was carried out by means of Naranjo algorithm. STATISTICA for Windows system was used. Results: Average age of the surveyed women made 25 years with prevalence patients in optimal reproductive age 62%. 1gr. - 70 (45%), 2gr. - 65 (42%), 3 gr. - 20 patients (13%). Statistically reliable differences in clinic weren't taped in groups. 47% women were marriage. 31% patients had children without differences in groups. Minority children were born before mother’s disease. FR was 0, 3. FR for simple replacements of generations should be 2, 15. Optimal FR - 4, 0. REC had 53% patients, 40% - due to AEDs. Comorbid REC was noted in 13% without differences in groups. Application of AED polytherapy enlarged REC frequency (p < 0,001). Conclusion: Fertility rate among women with epilepsy was lower optimal due to medical and social reasons. Reproductive disturbances were frequent side effect of antiepileptic drugs above at polytherapy. It’s necessary to monitor reproductive health in women with epilepsy during antiepileptic drugs treatment.