Silver salts and DBU cooperatively catalyzed domino reaction of propargylic alcohols with trifluoromethyl ketones: direct method to trifluoromethyl-substituted 5-alkylidene-1,3-dioxolane derivatives: Domino reaction of propargylic alcohols with trifluoromethyl ketones

A general and efficient synthesis of trifluoromethyl-substituted 5-alkylidene-1,3-dioxolanes using AgNO3 and DBU cooperatively catalyzed domino reaction of propargylic alcohols and trifluoromethyl ketones is described. The reaction tolerates a broad range of functional groups, and the desired products are obtained in good to excellent yields (62-99%) with acceptable diastereoselectivities. Copyright (c) 2016 John Wiley & Sons, Ltd.