Silver salts and DBU cooperatively catalyzed domino reaction of propargylic alcohols with trifluoromethyl ketones: direct method to trifluoromethyl-substituted 5-alkylidene-1,3-dioxolane derivatives: Domino reaction of propargylic alcohols with trifluoromethyl ketones
APPLIED ORGANOMETALLIC CHEMISTRY(2017)
Abstract
A general and efficient synthesis of trifluoromethyl-substituted 5-alkylidene-1,3-dioxolanes using AgNO3 and DBU cooperatively catalyzed domino reaction of propargylic alcohols and trifluoromethyl ketones is described. The reaction tolerates a broad range of functional groups, and the desired products are obtained in good to excellent yields (62-99%) with acceptable diastereoselectivities. Copyright (c) 2016 John Wiley & Sons, Ltd.
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Key words
silver salts,DBU,propargylic alcohols,trifluoromethyl ketones,domino reaction
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