Clinical Effect of Intravenous Thrombolysis Combined with Nicorandil Therapy in Patients with Acute St-Segment Elevation Myocardial Infarction

Purpose: To evaluate the effectiveness of intravenous thrombolysis in combination with nicorandil in the treatment of acute ST-segment elevation myocardial infarction (STEMI).Methods: Patients who developed acute STEMI and underwent intravenous thrombolysis in the hospital were selected and divided into observation group (n = 128) and control group (n = 114). Besides thrombolytic therapy, the observation group was also given 20 mg of nicorandil. The control group received conventional thrombolytic therapy only. Clinical effects and rehabilitation of patients were observed.Results: Cardiac troponin I (cTNI) level of the observation group was 4.0 +/- 1.5, 8.3 +/- 2.8 and 9.8 +/- 3.9 after 4, 12 and 24 h, respectively, which is much lower than 5.8 +/- 1.4, 11.4 +/- 2.7 and 13.2 +/- 4.2 in the control group (p < 0.05). ST-segment resolution of observation group was higher (44 +/- 14, 52 +/- 17, 69 +/- 21 and 80 +/- 18) % at different time points, compared with the control group (p < 0.05). The proportion of patients with Curtis-Walker score >3 points, and ventricular wall motion score (4.70 %; 1.38 +/- 0.11) in the observation group were both lower than those of the control group (21.00 %; 1.43 +/- 0.15) (p < 0.05). The difference in adverse cardiac events between the observation group (N = 6, 4.70 %) and control group (N = 12, 10.50 %) was not statistically significant (p > 0.05)Conclusion: Combining intravenous thrombolysis with nicorandil therapy can enhance myocardial perfusion level, reduce myocardial damage, improve cardiac function and decrease risk of arrhythmia for acute STEMI patients.