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Involvement of inhibition of RhoA/Rho kinase signaling in simvastatin-induced amelioration of neuropathic pain

Masahiro Ohsawa,Kei-ichiro Ishikura,Junpei Mutoh,Hiroaki Hisa

Neuroscience（2016）

Cited 19|Views3
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Abstract
•The mechanisms of simvastatin-induced amelioration of neuropathic pain were studied.•Spinal RhoA/Rho kinase signaling is activated in nerve-injured mice.•Spinal RhoA inhibition attenuated astrogliosis in the neuropathic pain.•Simvastatin may ameliorate neuropathic pain via the inhibition of spinal RhoA.
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Key words
ANOVA,HMG-CoA,ir,MARCKS,PBS,PKC,ROCK2
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