A terminal-block strategy for the amplified detection of DNA-break events

Jiepei Cao,Hai Shi,Xiaoxia Chen,Zihan Wang,Yaoyao Chen,Yongqian Shu,Xiaoli Zhu

Sensors and Actuators B: Chemical（2017）

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摘要

•A novel strategy is developed for the detection of DNA-break events.•Rolling circle amplification is integrated to improve the sensitivity.•Both double-strand break and single-strand break can be well detected.

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关键词

DNA break,Rolling circle amplification,Fenton reaction,Nicking endonuclease

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