Genetic variation in the major mitotic checkpoint genes associated with chromosomal aberrations in healthy humans

•Non-specific chromosomal aberrations (CAs) are detected in 1% of in vivo lymphocytes.•Causes of CAs in population are not known but they may be related to risk of cancer.•We genotyped 9 variants in mitotic checkpoint related genes on samples from healthy individuals.•Gene pairs were significantly associated with CAs: PTTG1-ZWILCH and PTTG1-ZWINT.•MAD2L1 and PTTG1 were the most common partners in any of the two-way interactions.