Intratumoral Genetic Heterogeneity Provides Additional Prognostic Significance Of The Cll Genomic Features

Background: Cytogenetic aberration remains the gold standard and basis for the long-standing hierarchical classification of CLL, with which 17p deletion (17p-) and 11q deletion (11q-) have been considered as independent adverse prognostic factors. But even in these subgroups, prognosis is also heterogenetic. CLL is also characterized by the coexistence of multiple genetic clones within the tumor. Whether this intratumoral genetic heterogeneity will further classify CLL has been less investigated.