Synthesis and immunostimulatory activity of substituted TLR7 agonists

Babatope Akinbobuyi,Lei Wang,Katherine C. Upchurch,Matthew R. Byrd,Charles A. Chang,Jeremy M. Quintana, Rachel E. Petersen,Zacharie J. Seifert,José R. Boquin,SangKon Oh,Robert R. Kane

Bioorganic & Medicinal Chemistry Letters（2016）

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摘要

Fifteen new substituted adenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds, were analyzed for TLR7 activity and for the selective stimulation of B cell proliferation. Several functionalized derivatives exhibit significant activity, suggesting their potential for use as vaccine adjuvants.

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