Assay and purity control of ticlopidine by thin layer chromatography
Jpc-journal of Planar Chromatography-modern Tlc(1994)
摘要
The application of HPTLC with UV or visible scanning densitometry provides a simple, rapid, and reliable system for the assay and purity control of ticlopidine. By use of silica gel plates with n-butanol-acetic acid - water (4 + 1 + 5, nu/nu) as mobile phase, all potential impurities were separated from ticlopidine and from each other, and could be quantified by densitometry.Detection limits at a signal-to-noise ratio of 2:1 were below 5 ng per spot. Linearity, reproducibility, and percentage recovery of ticlopidine from dosage forms have been calculated. The method provided reliable results when applied to the analysis of raw materials and tablets.
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关键词
TICLOPIDINE HYDROCHLORIDE, HPTLC, DENSITOMETRY, PURITY CONTROL
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