Liquid crystal biosensor for detecting ischemia modified albumin
Research on Chemical Intermediates(2016)
Abstract
Ischemia modified albumin detection has great significance in early diagnosis and treatment of myocardial ischemia. In this study, anti-IMA was immobilized on the surface of a glass slide using self-assembled DMOAP and PEI, the binding of antibody and antigen lead to topology-geomorphologic changes on the slide surface, which induced 5CB molecules orientation transformation and modulated light transmittance. Results showed that we can detect concentrations as low as 50 μg/mL IMA. Moreover, this method can be realized with label-free, easy operation without dependence on equipment, and can be observed by the naked eye.
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Key words
Biosensor, Liquid crystal, Ischemia modified albumin
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