Antibody-drug conjugate characterization by chromatographic and electrophoretic techniques.
Journal of Chromatography B（2016）
Abstract
•Reviewed the characterization of antibody drug conjugates (ADCs) by chromatographic and electrophoretic techniques.•The applications of RPLC, SEC, IEX, HIC, 2D-LC, GC, CE-SDS, CZE and CIEF are reviewed.•Including drug distribution, isomeric population, conjugation site, unconjugated drugs, charge variants, aggregates/fragments, etc.
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Key words
Antibody drug conjugate (ADC),Critical quality attribute (CQA),Drug-to-antibody ratio (DAR),Drug distribution,Peptide mapping,Charge variants,Aggregations,Free drug analysis
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