Antibody-drug conjugate characterization by chromatographic and electrophoretic techniques.

Tao Chen,Yan Chen,Cinzia Stella,Colin D. Medley,Jason Gruenhagen,Kelly Zhang

Journal of Chromatography B（2016）

引用 58|浏览15

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摘要

•Reviewed the characterization of antibody drug conjugates (ADCs) by chromatographic and electrophoretic techniques.•The applications of RPLC, SEC, IEX, HIC, 2D-LC, GC, CE-SDS, CZE and CIEF are reviewed.•Including drug distribution, isomeric population, conjugation site, unconjugated drugs, charge variants, aggregates/fragments, etc.

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关键词

Antibody drug conjugate (ADC),Critical quality attribute (CQA),Drug-to-antibody ratio (DAR),Drug distribution,Peptide mapping,Charge variants,Aggregations,Free drug analysis

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