Nutritional strategies to optimise cognitive function in the aging brain

Old age is the leading risk factor for neurodegenerative disease. Targeting nutrient sensing pathways through calorie restriction (CR) and intermittent fasting (IF) have proven to be effective treatments to delay ageing, increase healthspan, and postpone the onset of neurodegeneration. Anti-ageing compounds and low-protein, high-carbohydrate (LPHC) diet ratios have improved lifespan but the effects on delaying symptoms of neurodegeneration are still not well understood.