Dose Dependent Safety Study Of A Pre-workout Dietary Supplement In Resistance Training Participants: 253 Board #90 June 1, 9
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE(2016)
摘要
PURPOSE: To examine the short-term safety effects (7-d) of ingesting a pre-workout supplement (PWS), blood lipids and hepatorenal and muscle enzyme function before and 30-minutes following supplement ingestion. METHODS: We recruited 19 apparently healthy and recreationally active men and women (21.84±2.11 yr, 21.61±8.68 %fat, 26.94±3.84 kg/m2) with at least 6-months of resistance training, to participate in a double-blind, crossover, randomized and placebo-controlled manner. We instructed subjects to maintain their current diet and training regimens throughout the study. Supplements were (1) a dextrose placebo (PLA, 12 g/d); (2) a PWS supplement containing 5mg tetramethyluric acid, 4.7g B-alanine, 1.6g creatine nitrate, 1.0g arginine AKG, 250mg ascorbic acid, 150mg N-acetyl tyrosine, 150mg caffeine; or (3) PWS at ~150% dosage (PWS150) of the base formula for seven days, interspersed with 7-d of washout. On Day 1 (acute) and Day 7 (chronic), subjects were measured fasted (12 h), before ingesting their respective supplements. Testing also included a series of bench press, (BP), leg press (LP), and Wingate tests initiated 30-min after supplement ingestion. Data were analyzed using a repeated measure MANOVA. RESULTS: Overall, we observed no significant within or between group alterations for any biomarkers associated with glucose; bloods lipids including total cholesterol, LDL, HDL, triglycerides; kidney enzymes including creatinine and blood urea nitrogen (BUN); muscle enzymes such as lactate dehydrogenase (LDH) and creatine kinase (CK); and liver enzymes such as alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) function throughout the study (all makers, p≥0.05). CONCLUSION: The ingestion of the supplement examined in this study showed no adverse effects on blood lipids or hepatorenal and muscle enzyme function, with respective responses being similar to treatment with a PLA treatment condition. These findings are in agreement with other studies testing similar ingredients and longer studies appear to be safe to perform on performance related outcomes.
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关键词
supplement,resistance,dietary,training,pre-workout
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