Voriconazole Exposure Regulates Distinct Cell-Cycle And Terminal Differentiation Pathways In Primary Human Keratinocytes

Abstract Voriconazole is a second generation triazole antifungal used routinely in the care of solid organ and stem cell transplant recipients to both prevent and treat invasive fungal infections (1) . Voriconazole causes photosensitivity (2) and has been associated with a dose-dependent increased risk of developing cutaneous squamous cell carcinoma (cSCC).(3) Possible mechanisms suggested include direct phototoxicity by voriconazole or one of its metabolites (4) , oxidative stress pathway activation (5) , an indirect retinoid effect, or DNA damage repair inhibition (6) . This article is protected by copyright. All rights reserved.