Regulation of the cell surface expression of chloride transporters during epileptogenesis.

•Differential alterations in the plasma membrane expression of cation-chloride transporters were observed during epileptogenesis.•A shift in the cell surface expression of KCC2 and NKCC1 was detected during the early phase of epileptogenesis.•No change in the cell surface expression of KCC2 or NKCC1 was detected at the chronic stage.•Hyperexcitability during epileptogenesis may be a cumulative effect of multiple deficits impacting different aspects of GABAergic neurotransmission.