Exercise Training Improves Maximal Exercise Responses Similarly in Men with and without Type 1 Diabetes: 2787 Board #102 May 29, 3

Regular exercise is recommended to patients with type 1 diabetes. Exercise training improves peak O2 uptake (VO2peak) in patients with type 1 diabetes but central and peripheral contributions to the improvement are less clear. PURPOSE: To examine if individualized exercise training improves maximal exercise responses similarly in men with and without type 1 diabetes. METHODS: Eight men with type 1 diabetes (T1D) and eight healthy men (CON) matched for age (33.3±6.3 vs. 37.9±7.1 yrs, respectively, p>0.05), anthropometry, and VO2peak participated in a 1-year individualized exercise intervention. The subjects used heart rate monitors to collect data on their every single exercise session during the intervention; based on the data, they were given feedback on their exercise training monthly. Exercise training was similar in T1D vs. CON (mean±SD per month; p>0.05): 13±4 vs. 15±6 endurance training sessions, 3±1 vs. 3±3 resistance training sessions, 57±5 vs. 55±8 % of heart rate reserve, 16:58±6:07 vs. 16:52±4:39 h:min, 7759±4540 vs. 7762±3812 kcal, respectively. Before and after the intervention, the participants performed incremental cycling exercise to volitional fatigue, during which pulmonary VO2, O2 pulse (VO2/heart rate), and local active leg muscle (m. vastus lateralis) blood flow (Qvl; derived from the combination of near-infrared spectroscopy- and VO2 data) were monitored. One-way and repeated-measures ANOVAs were used to analyze the data. RESULTS: Exercise training increased VO2peak by 10% in T1D (from 45±5 to 49±6 mL/min/kg fat-free mass [FFM], p<0.01) and by 8% in CON (from 48±3 to 52±5 mL/min/kg FFM, p≤0.05), peak O2 pulse by 11% in T1D (from 0.26±0.03 to 0.28±0.03 mL/beat/kg FFM, p≤0.05) and by 11% in CON (from 0.26±0.02 to 0.29±0.03 mL/beat/kg FFM, p≤ 0.05), and peak Qvl by 8% in T1D (from 0.17±0.03 to 0.18±0.03 a.u., p≤ 0.05) and by 11% in CON (from 0.18±0.01 to 0.20±0.03 a.u., p≤0.05). The observed changes were similar in T1D vs. CON (p>0.05). CONCLUSION: A 1-year individualized exercise training intervention improves the surrogate markers of peak cardiac stroke volume (O2 pulse) and peak local active leg muscle blood flow (Qvl), and thus VO2peak similarly in adult men with and without type 1 diabetes. Supported by Tekes (40043/07) and the Ministry of Education and Culture (Finland).