The Novel Carboxamide Derivative Is-741 Reduces Neutrophil Chemoattractant Production By Bronchoalveolar Macrophages In Rats With Cerulein-Induced Pancreatitis Complicated By Sepsis

DIGESTION(1999)

Cited 18|Views14
No score
Abstract
Background/Aims: The priming mechanism of macrophages to secrete cytokines in acute pancreatitis is important for remote organ failure following septic complication. The effects of novel carboxamide derivative, IS-741, on neutrophil chemoattractant production by bronchoalveolar macrophages were studied in rats with cerulein-induced pancreatitis complicated by sepsis, Methods: Pancreatitis was induced by four intramuscular injections of cerulein (50 mu g/kg at 1-hour intervals). Pancreatitis rats were injected intraperitoneally with 10 mg/ kg of lipopolysaccharide (LPS) 6 h following the first cerulein injection as a septic challenge. Pancreatitis rats received a continuous intravenous injection of IS-741 (3 mg/kg/h) 30 min before the septic challenge. Results: Intense mononuclear cell infiltration and lung hemorrhage occurred in untreated pancreatitis rats complicated with sepsis, but hemorrhage was not seen in septic pancreatitis rats receiving a continuous intravenous injection of IS-741 shortly before sepsis induction. The IS-741-treated rats had lower serum concentrations of cytokine-induced neutrophil chemoattractant (CINC), as well as fewer the pulmonary neutrophils and infiltrates immunoreactive for CINC or Mac-1 (CD11b/CD18). Conclusion: The novel carboxamide derivative IS-741 reduced CINC production by bronchoalveolar macrophages and effectively prevented pancreatitis-associated lung injury following the septic challenge.
More
Translated text
Key words
pancreatitis, septic complication, cytokine-induced neutrophil chemoattractant, bronchoalveolar macrophage
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined