The uncertain future for central dogma

In "Rethinking Genetic Determinism" Paul H. Silverman questioned one of the pillars of molecular genetics and documented the need for determinism's expansion into a far more valid and reliable representation of reality. Silverman firmly believed that we needed a wider-angled model, with a new framework and terminology, to display what we know and to guide future discovery. He also viewed this model as being a catalyst for exploring uncertainty, the vast universeof chance differences on a cellular and molecular level that can considerablyinfluence organismal variability. Uncertainty not only undermines molecular genetics' primary pillars of determinism and reductionism, but also provides a bridge to future research.