Arid1a Is Recurrently And Significantly Mutated In Follicular Lymphoma (Fl) And Impairs Dna Repair Efficiency

FL is the most common indolent nodal lymphoma and considered incurable for the majority of patients. Virtually all patients eventually develop resistant disease, and up to 45% histologic transformation (tFL) with poor outcome. Alterations associated with progression to tFL include increased copy number variations (e.g. CDKN2A deletions, MYC amplification), acquisition of additional translocations (e.g. MYC or BCL6), and higher mutation load (including TP53). However the underlying molecular mechanisms promoting this genomic instability remain elusive. Interestingly, histologic transformation occurs at a remarkably constant rate of ~3% per year implying a rather stochastic process.