Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease

•DiceCT was utilized to image lesions while preserving histologic validation.•Novel soaking technique in CCM murine model using micro-CT imaging.•CCM lesion burden identified on micro-CT images was verified with histology.•Micro-CT volumetric analysis of lesion burden correlated with histologic area.•Micro-CT can complement histology to optimize workflow and maximize information.