Spirocyclic amino alcohol building blocks prepared via a Prins-type cyclization in aqueous sulfuric acid
Tetrahedron Letters（2016）
Abstract
•Prins-type spirocyclization was conducted in 70% sulfuric acid.•The aqueous protocol was applied to basic substrates for the first time.•The resulting building blocks are useful in antidiabetic drug design.
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Key words
Prins spirocylization,Amino alcohols,Bifunctional building blocks,High-Fsp3 scaffolds,Privileged structures
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