Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive
LETTERS IN DRUG DESIGN & DISCOVERY（2016）
Abstract
An efficient method was developed for the synthesis of pamidronic acid involving the reaction of beta-alanine with three equivalents of phosphorus trichloride and two equivalents of phosphorous acid at 75 degrees C in the presence of 0.3 or 0.6 equivalents of [BMIM][PF6] as an additive.
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Key words
Pamidronic acid,best synthesis,additive,ionic liquids,intermediate
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