A dipeptidyl peptidase-4 inhibitor ameliorates hypertensive cardiac remodeling via angiotensin-II/sodium-proton pump exchanger-1 axis

Haruya Kawase,Yasuko Bando,Kazuyuki Nishimura,Morihiko Aoyama,Akio Monji,Toyoaki Murohara

Journal of Molecular and Cellular Cardiology（2016）

引用 24|浏览10

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摘要

•Distinct action of dipeptidyl peptidase-4 inhibitors on hypertension•BP lowering mechanism induced by teneligliptin via non-canonical AngII pathway•Novel mechanisms that modulate hypertensive cardiac hypertrophy via NHE-1•Regulatory role of intracellular acidification via NHE-1 in cardiac hypertrophy

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关键词

Dipeptidyl peptidase-4 inhibitor,Hypertension,Cardiac remodeling,Angiotensin-II,Sodium-proton pump exchanger

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