Stimulation of cellular senescent processes, including secretory phenotypes and anti-oxidant responses, after androgen deprivation therapy in human prostate cancer.
The Journal of Steroid Biochemistry and Molecular Biology(2017)
摘要
•Cellular senescence phenotypes are triggered by hormone ablation in an animal level.•Secretory phenotypes and anti-oxidant responses were accompanied in human specimens.•These responses are novel targets for prevention of endocrine resistance.
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关键词
Cellular senescence,Senescence-associated secretory phenotype,Anti-oxidant response,Prostate cancer,Androgen deprivation therapy
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