Stimulation of cellular senescent processes, including secretory phenotypes and anti-oxidant responses, after androgen deprivation therapy in human prostate cancer.

The Journal of Steroid Biochemistry and Molecular Biology(2017)

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摘要
•Cellular senescence phenotypes are triggered by hormone ablation in an animal level.•Secretory phenotypes and anti-oxidant responses were accompanied in human specimens.•These responses are novel targets for prevention of endocrine resistance.
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关键词
Cellular senescence,Senescence-associated secretory phenotype,Anti-oxidant response,Prostate cancer,Androgen deprivation therapy
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