Application of ambient ionization high resolution mass spectrometry to determination of the botanical provenance of the constituents of psychoactive drug mixtures

⿢DART-HRMS used for rapid analysis of the psychoactive plant brew Ayahuasca.⿢Species biomarkers were confirmed without need for sample preparation.⿢PCA was used for determination of the originating plant species of Ayahuasca brews.⿢DART-HRMS provides rapid means to analyze forensic samples comprised of complex matrices.