Hfpef And Hfref Display Different Anabolic Phenotypes As Assessed By Igf-1 And Igfbp-1

•Heart failure with preserved ejection (HFpEF) and heart failure with reduced ejection fraction (HFrEF) differ regarding insulin-like growth factor 1 (IGF-1), with higher concentrations in HFpEF.•HFpEF and HFrEF phenotypes were similar regarding increased IGF binding protein 1 (IGFBP-1) concentrations.•IGFBP-1 was associated with N-terminal pro-brain natriuretic peptide in both HFpEF and HFrEF.•Higher IGF-1 levels were associated with better prognosis in HFrEF but not in HFpEF.