Immune-competent human skin disease models

•Skin disease drug development requires immune-competent in vitro human models.•Skin disease examples: fibrosis, autoimmune, psoriasis, cancer and contact allergy.•Current animal and in vitro methods incorporating human immunology.•Skin-on-chip technology enables next-generation human immune-competent skin models.•Induced pluripotent stem cells could be key for personalized medicine.