Immune-competent human skin disease models

Drug Discovery Today(2016)

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摘要
•Skin disease drug development requires immune-competent in vitro human models.•Skin disease examples: fibrosis, autoimmune, psoriasis, cancer and contact allergy.•Current animal and in vitro methods incorporating human immunology.•Skin-on-chip technology enables next-generation human immune-competent skin models.•Induced pluripotent stem cells could be key for personalized medicine.
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