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TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis

Emna Mahfoudhi,Ibtissam Talhaoui,Xenia Cabagnols,Véronique Della Valle,Lise Secardin, Philippe Rameau,Olivier A. Bernard,Alexander A. Ishchenko,Salem Abbes, William Vainchenker,Murat Saparbaev,Isabelle Plo

DNA Repair（2016）

Cited 20|Views22
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Abstract
•TET2 slows down the S phase of the cell cycle.•TET2 induces chromosomal and centrosomal abnormalities.•TET2-mediated 5-fC or 5-caC elevation in Tdg deficient context leads to mutagenesis.
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Key words
TET2,5-hmC,TDG,Genetic instability,Cell cycle
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