Chemical composition and biological activities of Pouteria campechiana (Kunth) Baehni

The present study was conducted to evaluate the analgesic, anti-inflammatory and gastroprotective activities of ethanol, de-fatted ethanol extracts and n-hexane fractions of Pouteria campechiana (Kunth) Baehni leaves and seeds.Further chemical analysis was done to isolate and identify its bioactive compounds.The seeds ethanolic extract produced 85% inhibition of inflammation in the rat paw oedema test at the dose of 100 mg/kg after 4 h (p<0.05).On the other hand, the leaves ethanolic extract (200 mg/kg) exhibited maximum analgesic activity after 90 min (p<0.05) in the hot plate test.Both leaves and seeds ethanolic extracts showed significant decreases in gastric ulcer number and severity (p<0.05).Phytochemical investigation of P. campechiana leaves and seeds yielded six compounds: protocatechuic acid (C 1 ), gallic acid (C 2 ), quercetin (C 3 ), myricetin (C 4 ), myricetin-3-O-α-L-rhamnoside (C 5 ) and myricetin-3-O-β-galactoside (C 6 ).The study supports the use of P. campechiana in traditional medicine for conditions associated with inflammation, pain and peptic ulcers.